MOTS-c

Name: MOTS-c
SKU: MS10
Price: 39.99 USD
Availability: InStock

1627580-64-6

Mitochondrial ORF of the 12S rRNA type-c

Mitochondrial-derived peptide for metabolic-homeostasis research.

Mass

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Release standard

99%+

Minimum purity by HPLC for every compound lot released.

Analyses per lot: 2
Methods: HPLC · MS
Laboratory: Independent

Molecular profile

CAS number: 1627580-64-6
Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6 g/mol
Type: Mitochondrial-derived peptide, 16 residues
Sequence: MRWQEMGYIFYPRKLR
Catalogue number: MS10
Nominal mass: 10 mg

Storage and handling

Appearance: Lyophilized powder
Solubility: Soluble in water
Storage: -20 °C, sealed and protected from light
Reconstituted: Refrigerate at 2-8 °C, use promptly
Classification: Laboratory research use only

Overview

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial genome, one of a small class of mitochondrial-derived peptides discovered to act as cellular signaling molecules.

In preclinical research, MOTS-c is studied for its role in metabolic homeostasis, including AMPK-pathway activation, glucose handling in muscle-cell models, and the cellular response to metabolic and exercise-mimetic stress. Its mitochondrial origin makes it a distinctive tool in studies connecting mitochondrial signaling to whole-cell metabolism.

Each vial contains 10 mg of lyophilized MOTS-c, sealed for laboratory use. This material is supplied strictly for in-vitro research and laboratory experimentation and is not for human or veterinary use of any kind.

Documented research areas

Mitochondrial-derived peptide signaling
AMPK-pathway activation studies
Glucose-metabolism and insulin-sensitivity models
Exercise-physiology and metabolic-stress research

Certificate of analysis

Available on request

Each lot is released against an HPLC purity result and a mass-spectrometry identity confirmation. Tested by an independent laboratory in Los Angeles, CA. Send us your lot number and we'll email that lot's report.

Catalog: MS10
Release standard: ≥ 99% purity

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Peer-reviewed literature

Selected published research on this compound

Independent, peer-reviewed work describing laboratory and clinical study of this compound. Listed so the research context on this page can be read at the source rather than taken on our word. These are not claims about this product.

01

Cell Metabolism 2015

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Lee C, Zeng J, Drew BG, et al.
02

Nature Communications 2021

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Reynolds JC, Lai RW, Woodhead JST, et al.